Dostoevsky’s French reception: from Vogüé, Gide, Shestov and Berdyaev to Marcel, Camus and Sartre (1880-1959)

This history of Dostoevsky’s reception in France draws from critical responses, translation analysis, and the comparative analysis of adaptations as well as intertextual dialogues between fictional, critical and philosophical texts. It begins from the earliest translations and critical accounts of the 1880s and 1890s, such as Eugène-Melchior de Vogüé’s seminal moralist reading. It then traces modernist responses and adaptations from the turn of the century to the twenties. Existential readings and re-translations dating from the arrival of émigré critics and religious philosophers in the wake of the Russian Revolution are examined, assessing the contribution of these émigré readings to emerging existential readings and movements in France. Finally, French existentialist fiction is analysed in terms of its intertextual dialogue with Dostoevsky’s work and with speculative and critical writings of French existentialist thinkers on and around the philosophical reflections expressed in Dostoevsky’s fiction. By following specifically the existential and existentialist branches of Dostoevsky’s French reception, an overlooked aspect of the history of French, Russian and European existentialisms comes to the fore, reframed within a pivotal period in the history of European intercultural exchange, and of transmodal literary and philosophical discourse

Self-concept clarity and women\u27s sexual well-being

The purpose of this study was to examine the role of self-concept clarity, a core structural aspect of self-concept, in women\u27s sexual well-being. A convenience sample of 261 women aged 18 years and over {M=25.8, &pound;D=7.9) completed an online survey that measured self-concept clarity, three aspects of sexual well-being (sexual self-ef&ntilde;cacy, sexual self-esteem and sexual satisfaction), and four structural dimensions of sexual identity (commitment, synthesis/integration, exploration, and orientation identity uncertainty). A series of multiple mediation analyses, followed by post-hoc bootstrap tests of the difference between mediation effects, revealed that self-concept clarity is indirectly related to the measures of sexual well-being, and that these relationships are mediated by the two &quot;investment-related&quot; dimensions of sexual identity: commitment and synthesis/integration. These results suggest that women with a more broadly and coherently integrated sexual identity are also better able to make healthy and positive choices in the sexual domain and experience more satisfaction with their sex lives, i^ore generally, the results highlight the potential importance of including structural aspects of self-concept in explanations of women\u27s sexual well-being.<br /

ASSOCIATING SNPS WITH BINARY TRAITS

Association mapping uses statistical analyses to test for relationships between genomic markers called single nucleotide polymorphisms (SNPs) and traits. This research focuses on the use of logistic regression to assess the additive, dominance, and epistatic effects when investigating associations between SNPs and binary traits, such as disease status. A very specific phenomenon that results in infinite maximum likelihood estimates (MLEs) of logistic regression parameters, called quasi-separation of points (QSP), is investigated. We provide a solution that relies on the use of Firth’s MLE to estimate logistic regression parameters. Simulated and real data are utilized to investigate the use of Firth’s MLE in a QSP setting

Prospectus, August 23, 1976

$7.4 MILLION BUDGET APPROVED BY PARKLAND BOARD OF TRUSTEES; PC radio permit sought; Calendar of Events; Stephen D. Fisher; Editorial: Letter to a Parkland mommy; Greetings from the school, Stu-Go, and Prospectus: Well Hello, Hello, Hello….....; Food service training prog. to begin; Use your facilities: Game Room open daily; 67 hours and 40 minutes: Julie Corley star rocker; 5 new teachers; Stu-Go elections Sept. 14, 15; Attention Veterans; Projected student government budget; National competitors: Debate needs new talent; Parkland G.E.D.: Program helps diploma-seekers; Sign up for ladder tournaments; Get involved : Poli-sci for Today -- with a little Econ 000.1 thrown in; Donkeys or elephants, the choice is yours; Story of the year: Schorr addresses Parkland; Lost?... and found; Got a dime?; Peer Counseling begins; C-U awareness taught; Cubs-Cards trip Sept. 5; Gen. Ed. courses offered; Creative Writing offered this fall; Peschka receives$10,000; University Theatre Announces 76-77 Schedule; Peggy Cass Stars in Sullivan; Kooning opens Krannert season; Student tax cut proposed; Classifieds; Abbey elected pres. NJCAA coaches; Athletic Schedules \u2776\u27; A Warm Welcome to Parkland College; Directory of Offices and Services; Items of Interest About the Campus; Campus Services - Day and Eveninghttps://spark.parkland.edu/prospectus_1976/1015/thumbnail.jp

From discs to planetesimals I: evolution of gas and dust discs

I review the processes that shape the evolution of protoplanetary discs around young, solar-mass stars. I first discuss observations of protoplanetary discs, and note in particular the constraints these observations place on models of disc evolution. The processes that affect the evolution of gas discs are then discussed, with the focus in particular on viscous accretion and photoevaporation, and recent models which combine the two. I then discuss the dynamics and growth of dust grains in discs, considering models of grain growth, the gas-grain interaction and planetesimal formation, and review recent research in this area. Lastly, I consider the so-called "transitional" discs, which are thought to be observed during disc dispersal. Recent observations and models of these systems are reviewed, and prospects for using statistical surveys to distinguish between the various proposed models are discussed.Comment: 28 pages, 9 figures. Refereed review chapter for proceedings of VLTI summer school on "Circumstellar discs and planets at very high angular resolution", to appear in New Astronomy Reviews. See http://www.vlti.org/ for more detail

Decreased anticipated pleasure correlates with increased salience network resting state functional connectivity in adolescents with depressive symptomatology

Previous studies have found dysfunctional resting state functional connectivity (RSFC) in depressed patients. Examining RSFC might aid biomarker discovery for depression. However RSFC in young people at risk of depression has yet to be examined. 35 healthy adolescents (13-18 yrs old.) were recruited. 17 scoring high on the Mood and Feelings Questionnaire (MFQ > 27 (High Risk: HR), and 18 scoring low on the MFQ < 15 (Low Risk: LR) matched on age and gender. We selected seed regions in the salience network (SN: amygdala and pregenual anterior cingulate cortex (pgACC)) and the central executive network (CEN: dorsal medial prefrontal cortex (dmPFC)). Mood and anhedonia measures were correlated with brain connectivity. We found decreased RSFC in the HR group between the amygdala and the pgACC and hippocampus and precuneus. We also found decreased RSFC in the HR group between the pgACC and the putamen and between the dmPFC and the precuneus. The pgACC RSFC with the insula/orbitofrontal cortex correlated inversely with the anticipation of pleasure in all subjects. Increased RSFC was observed between the pgACC and the prefrontal cortex and the amygdala and the temporal pole in the HR group compared to the LR group. Our findings are the first to show that adolescents with depression symptoms have dysfunctional RSFC between seeds in the SN and CEN with nodes in the Default Mode Network. As increased connectivity between the pgACC and the insula correlated with decreased ability to anticipate pleasure, we suggest this might be mechanism underlying the risk of experiencing anhedonia, a suggested biomarker for depression

Rapid nano-gram scale screening method of micro-arrays to evaluate drug-polymer blends using high-throughput printing technology

A miniaturized, high-throughput assay was optimized to screen polymer-drug solid dispersions using a 2-D Ink-jet printer. By simply printing nanoliter amounts of polymer and drug solutions onto an inert surface, drug:polymer micro-dots of tunable composition were produced in an easily-addressable micro-array format. The amount of material printed for each dried spot ranged from 25 ng to 650 ng. These arrays were used to assess the stability of drug:polymer dispersions with respect to recrystallization, using polarized light microscopy. One array with a panel of 6 drugs formulated at different ratios with Poly (vinylpyrrolidone-vinyl acetate) copolymer (PVPVA) was developed to estimate a possible bulk (gram-scale) approximation threshold from the final printed nano amount of formulation. Another array was printed at a fixed final amount of material to establish a literature comparison of one drug formulated with different commercial polymers for validation. This new approach may offer significant efficiency in pharmaceutical formulation screening, with each experiment in the nano-micro-array format requiring from 3 up to 6 orders of magnitude lower amounts of sample than conventional screening methods

Chronic Neurobehavioral Sex Differences in a Murine Model of Repetitive Concussive Brain Injury

Traumatic brain injury (TBI) resulting from repeated head trauma is frequently characterized by diffuse axonal injury and long-term motor, cognitive and neuropsychiatric symptoms. Given the delay, often decades, between repeated head traumas and the presentation of symptoms in TBI patients, animal models of repeated injuries should be studied longitudinally to properly assess the longer-term effects of multiple concussive injuries on functional outcomes. In this study, male and cycling female C57BL/6J mice underwent repeated (three) concussive brain injuries (rCBI) delivered via a Leica ImpactOne cortical impact device and were assessed chronically on motor (open field and rotarod), cognitive (y-maze and active place avoidance), and neuropsychiatric (marble-burying, elevated zero maze and tail suspension) tests. Motor deficits were significant on the rotarod on the day following the injuries, and slight impairment remained for up to 6 months. All mice that sustained rCBI had significant cognitive deficits on the active place avoidance test and showed greater agitation (less immobility) in the tail suspension test. Only injured male mice were significantly hyperactive in the open field, and had increased time spent in the open quadrants of the elevated zero maze. One year after the injuries, mice of both sexes exhibited persistent pathological changes by the presence of Prussian blue staining (indication of prior microbleeds), primarily in the cortex at the site of the injury, and increased GFAP staining in the perilesional cortex and axonal tracts (corpus callosum and optic tracts). These data demonstrate that a pathological phenotype with motor, cognitive, and neuropsychiatric symptoms can be observed in an animal model of rCBI for at least one year post-injury, providing a pre-clinical setting for the study of the link between multiple brain injuries and neurodegenerative disorders. Furthermore, this is the first study to include both sexes in a pre-clinical long-term rCBI model, and female mice are less impaired functionally than males